Πλοήγηση ανά Θέμα "primary biliary cirrhosis"
Αποτελέσματα 1-20 από 41
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Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis
(2022)Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ... -
Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases
(2015)Background: The liver asialoglycoprotein receptor (ASGPR) is the only organ-specific autoantigenic target in autoimmune hepatitis (AIH) patients and corresponding autoantibodies (Abs) have been suggested aiding in the ... -
A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis
(2008)Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell ... -
The challenges of primary biliary cholangitis: What is new and what needs to be done
(2019)Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive anti-mitochondrial autoantibodies (AMA), female preponderance and progression ... -
Decreased serum DNase1-activity in patients with autoimmune liver diseases
(2017)Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first ... -
Early primary biliary cirrhosis: A new association with erythema nodosum of unknown origin
(2010)Primary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, ... -
Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis
(2019)Background & Aims: Primary biliary cholangitis (PBC) predominantly affects middle-aged women; there are few data on disease phenotypes and outcomes of PBC in men and younger patients. We investigated whether differences ... -
Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis
(2020)Background & Aims: Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of ... -
Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis
(2020)Background & Aims: Patients usually receive a diagnosis of primary biliary cholangitis (PBC) at an early stage, based on biochemical analyses. We investigated the proportion of patients who progress to moderate or advanced ... -
FibroMeter scores for the assessment of liver fibrosis in patients with autoimmune liver diseases
(2021)Introduction and Objectives: We assessed FibroMeter virus (FMvirus) and FibroMeter vibration-controlled transient elastography (FMVCTE) in 134 patients with autoimmune liver diseases [ALD, autoimmune hepatitis (AIH) and ... -
Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece
(2017)Background & aims Primary biliary cholangitis (PBC) is a disease with rising prevalence and considerable geographical variation. To describe the prevalence, spatial and time distribution, baseline characteristics, response ... -
Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin within the Normal Range and Normalization of Alkaline Phosphatase
(2020)INTRODUCTION:In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis. Current treatment goals do not aim for normalization of surrogate ... -
Hair dyes as a risk for autoimmunity: From systemic lupus erythematosus to primary biliary cirrhosis
(2013)Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium sized ... -
Hemopoietic progenitor cells and bone marrow stromal cells in patients with autoimmune hepatitis type 1 and primary biliary cirrhosis
(2003)Background/Aims: Autologous hematopoietic stem cell transplantation has been used in severe cases of autoimmunity. We investigated whether hemopoietic progenitor cells and/or bone marrow (BM) microenvironment are affected ... -
IgA anti-b2GPI antibodies in patients with autoimmune liver diseases
(2008)Introduction Recently, we reported a high prevalence of immunoglobulin G and/or immunoglobulin M anticardiolipin antibodies (aCL) in patients with autoimmune liver diseases, namely, autoimmune hepatitis (AIH), primary ... -
Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis
(2017)Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ... -
Infectious triggers of primary biliary cirrhosis: Do we know enough?
(2011)Primary biliary cirrhosis (PBC) is an immune mediated liver disease directed against the biliary epithelial cells of the small bile ducts. The disease is characterised by circulating antimitochondrial antibodies (AMA), as ... -
Lack of association between appendectomy and primary biliary cirrhosis
(2006)Objective. In view of the possible implication of various environmental factors in the pathogenesis of primary biliary cirrhosis (PBC), the role of appendectomy in patients with PBC and other chronic liver diseases from ... -
Late-onset Pompe's disease in a hemodialysis patient: A first case report
(2018)A 37-year-old hemodialysis patient appeared with unusual somnolence during 2 successive hemodialysis sessions. Blood gas analysis revealed hypercapnic respiratory failure and spirometry restrictive lung disease. After ... -
Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR
(2015)Background/Aim. Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis ...